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Zoltan Molnar on subplate neurons and cortical development CSN Podcasts
Episode 3 05.05.2025
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What happens to the temporary scaffolding cells that help build the brain during development, and could their remnants explain cognitive disorders? Neuroscientist Zoltan Molnar from the University of Oxford returns to the Convergent Science Network podcast after 11 years to discuss how transient cell populations in the subplate regulate cortical circuit formation, and why the prolonged timeline of human brain development may be both a vulnerability and an evolutionary advantage. Subscribe for more from the Convergent Science Network podcast series. Zoltan Molnar, a leading expert on cortical development and subplate neurobiology at the University of Oxford, joins Paul Verschure and Tony Prescott at the BCBT school for a follow-up conversation more than a decade after his first CSN interview. The discussion centers on how the brain’s prolonged developmental timeline, particularly in humans, creates extended periods where transient circuits coexist with maturing adult connectivity. Molnar explains that human brain development is remarkably prolonged compared to other mammals. Thalamic projections arrive near the cortex early but accumulate in the subplate for months before making their final connections, a process that takes hours in mice but months in humans. This raises fundamental questions about whether developmental time scales with life expectancy and whether a meta-level controller ensures stability during this extended self-organizing process. The conversation explores the subplate as a transient scaffolding layer: the earliest-generated neurons that receive the first synapses, guide thalamocortical connectivity, and then partially disappear through programmed cell death. Molnar argues that similar transient populations exist elsewhere, particularly in the thalamic reticular nucleus, which may serve as the subplate equivalent for corticothalamic projections. The discussion addresses an ongoing scientific debate about whether subplate cells truly disappear or persist into adulthood. Molnar presents evidence for preferential cell death between postnatal days 2-8 in rodents, while acknowledging that subpopulations born at different times may have different fates. The remaining interstitial cells appear to regulate local arousal, attention, and sleep states in the adult brain. The broader implication is that abnormal development of these transient circuits may underlie cognitive disorders, connecting developmental neurobiology directly to clinical neuroscience. Part of the Convergent Science Network podcast series from the BCBT School.
Tagged as:
brain development Cells Cognitive Disorders cortical development Subplate subplate neurons Transient
About the author call_made
Both the triumphs of humanity and its most evil deeds have resulted from collaboration. In a time where humanity is required to aspire to the former and minimize the latter, the question arises of how collaboration arises and why it fails. Surprisingly, this phenomenon, so central to who we are, is not well understood. Hence, a collaborative effort is required to understand collaboration in its full biological, psychological, sociological, cultural, and economic complexity and to translate this understanding into operational impact. This series of podcasts is one step toward achieving these complementary goals. The Collaboration Podcast presents interviews with people who are central orchestrators of collaboration in various domains including business, government, science, art, health, sustainability, and the military. The discussions were conducted by Prof. Dr. Paul F.M.J. Verschure and members of the Program Advisory Committee of the Ernst Strungmann Forum on Collaboration (https://www.esforum.de/forums/ESF32_Collaboration.html) during 2021 and had the goal to sketch a map of opportunities, challenges, and obstacles in human collaboration. The forum took place in May 2022, and now we would like to share this series of interviews with a broader audience. The full report of the Forum will be published in 2023 by MIT Press. The podcast was produced by the Convergent Science Network (https://www.convergentsciencenetwork.org/). Context: The stability of social systems depends critically on realizing sustainable methods of “collaboration,” yet how and by which means collaboration is achieved is not clearly understood; neither are the conditions or processes that lead to its breakdown or failure. Collaboration can be understood as cooperation between agents toward mutually constructed goals. Part of the reason for our lack of understanding is that the phenomenon of collaboration is, by nature, a highly multidisciplinary problem, and effective research into its complexities has been difficult to achieve across the broad range of scientific and technical disciplines involved. The need for a fundamental understanding of collaboration, however, has become increasingly important. Not only does humankind demand answers as it attempts to address critical challenges at multiple scales (e.g., climate change, migration, enhanced automation, social and economic inequality), but ever-increasing technological and economic means of interconnecting people and societies are disrupting long-established, familiar patterns of how we interact. Radical technological changes that are ongoing have the potential to reshape collaboration in ways that are currently hard to predict or influence (e.g., by altering configurations in interaction, information creation, and modes of communication). On one hand, such changes could disrupt hitherto stable forms of collaboration by affecting critical communication channels and traditional roles, as can be observed in the rapidly changing patterns in governance, commerce, and social interaction. Conversely, technology could lead to the emergence of novel, successful forms of collaboration that deviate from traditional “hierarchical” architectures. Evidence of this can be seen in areas as diverse as highly automated manufacturing plants, the open science movement, collaborative software repositories, user-centered services, and the sharing of economy-based modes of organization. Without a fundamental understanding of the mechanisms, processes, and boundary conditions of collaboration, it is not possible to evaluate or predict which of these possible scenarios are sustainable or even plausible. The Forum “How Collaboration Arises and Why it Fails” (May 8–13, 2022, Location: Frankfurt am Main, Germany) Chairs: Andreas Roepstorff and Paul Verschure Program Advisory Committee: Jenna Bednar, Julia R. Lupp, Bhavani R. Rao , Andreas Roepstorff, Ferdinand von Siemens, and Paul Verschure
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